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Causes and solutions for histamine intolerance

Table of Contents

What is histamine intolerance?

Histamine is a biological substance (biogenic amine) that is produced when an amino acid is broken down. It used to be thought that it only plays a role in triggering allergic reactions (it is mainly released by mast cells during allergic processes), but today we know that it has other functions. Histamine, for example, enables nerve cells to communicate with each other and is therefore important for neurotransmission. It is only present in the body for a very short time, only 10-60 minutes.

What causes histamine intolerance?

Contrary to popular belief, histamine intolerance in humans and animals is not only directly caused by the high histamine levels in food, but by the presence of another substance. This substance is lysine, which is used as a flavour enhancer in the form of free amino acids.

In the body, cadaverine, which is formed from ingested lysine, is broken down by the enzyme DAO. Cadaverine is a powerful toxin and therefore has priority in the degradation process, making it impossible to break down histamine.

The body wants to get rid of cadaverine as quickly as possible – so histamine remains in the body in large quantities.

Lysine is a free amino acid in many processed foods, e.g. crisps, snack foods, etc.

What are the problematic foods?

A standard recommendation is to avoid foods with high histamine content. This may help relieve symptoms, but it does not solve the cause.

LPS bacteria

Another cause of histamine intolerance is the level of harmful LPS bacteria in the gut microbiome.

Lysine, which is provided to the body as a free amino acid, produces cadaverine. It shocks the mast cells, which produce high levels of histamine.

Pesticide residues in food – glyphosate

The third cause of histamine intolerance is the blocking effect of the herbicide glyphosate on the enzyme DAO (cytochrome p450). In the body, cadaverine, which is formed from ingested lysine, is broken down by the DAO enzyme.

Glyphosate and histamine intolerance

This combination leads to histamine intolerance.

How can histamine intolerance be remedied?

The solution is to rid the microbiome of the LPS bacteria present.
Avoid foods that contain lysine as a free amino acid.
Avoid eating industrially produced pork and poultry, which are almost exclusively raised on industrial feed containing lysine.

Fulvicherb-Synergy helps to restore the gut microbiome and so helps with histamine sensitivity.


Read the article in German: Ursachen und Lösungen für Histamin-Intoleranz

Read the article in Polish: Przyczyny i rozwiązania dla nietolerancji histaminy (wrażliwości na histaminę)


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